Health data have unique characteristics in how fragmented, sensitive, complex, and regulated they are. These characteristics create challenges in developing impactful solutions and in adopting new technological breakthroughs. Using examples of real-world implementations, this session will highlight some of the emerging solutions to address the challenges with large scale health data integration and analysis. Federal policies like TEFCA (Trust Exchange Framework and Common Agreement) and EHR (electronic health records) certification requirements, along with new technologies like Web 3.0, blockchain, and common data standards for interoperability are creating possibilities that need to be tested, adopted, and further refined.