Description

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Neuroimaging involves generating images of the central nervous system to understand its structure, function, or pharmacology. The field is rapidly evolving, with new techniques emerging for data acquisition and advanced statistical learning methods being developed for data analysis. Recently, there’s been a surge in collecting neuroimaging data across healthcare, research, and clinical trials. Such imaging aids in diagnosing and prognosing brain diseases, like multiple sclerosis, dementia, and schizophrenia. It helps identify issues such as strokes, tumors, and brain swelling. Current applications, like MRI for multiple sclerosis monitoring, still present opportunities for enhanced statistical modeling.

Large biomedical studies gather extensive neuroimaging data, including sMRI, DWI, and fMRI. These studies target the human brain’s connectivity, understanding brain disorders, monitoring neuropsychiatric progression, and diagnosing brain cancer. The influx of data can significantly enhance our comprehension of the brain and help in creating effective treatments for neurological and psychiatric conditions. However, analyzing this data necessitates the progression of statistical learning techniques, encompassing image processing and population-based statistical evaluations. While topics like image enhancement and predictive models are of interest, the growth in statistical analysis lags behind neuroimaging advancements, challenging the application of research in clinical settings.

This workshop aims is to provide a comprehensive discussion of mathematical and statistical challenges in neuroimaging data analysis from neuroimaging techniques to large-scale neuroimaging studies to statistical learning methods. This research topic is important and timely to ensure that researchers are equipped with the tools and methods needed to handle the large and complex datasets and to produce reliable and reproducible research findings.

This workshop will include a poster session for early career researchers (including graduate students). In order to propose a poster, you must first register for the workshop, and then submit a proposal using the form that will become available on this page after you register. The registration form should not be used to propose a poster.

The deadline for proposing is May 20, 2024. If your proposal is accepted, you should plan to attend the event in-person.

Organizers

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J K
Jian Kang University of Michigan
J K
John Kornak University of California, San Francisco
N L
Nicole Lazar Penn State University
T N
Thomas Nichols University of Oxford
H O
Hernando Ombao King Abdullah University of Science and Technology
S L S
Sean L. Simpson Wake Forest University School of Medicine
A S
Anuj Srivastava Florida State University
T Z
Tingting Zhang University of Pittsburgh
H Z
Hongtu Zhu University of North Carolina at Chapel Hill

Speakers

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M A
Markus Axer Institute of Neurosciences and Medicine (INM-1), Research Centre Jülich
S B
Sumanta Basu Cornell University
M D
Maxime Descoteaux Université de Sherbrooke
A E
Ani Eloyan Brown University
J F
Jianfeng Feng University of Warwick
M F
Mark Fiecas University of Minnesota
T G
Tanya Garcia University of North Carolina at Chapel Hill
S G
Sharmistha Guha Texas A&M University
J H
Jaroslaw Harezlak Indiana University Bloomington
F J
Fei Jiang University of California, San Francisco
T J
Timothy Johnson University of Michigan
J K
Jian Kang University of Michigan
R K
Robert Kass Carnegie Mellon University
L K
Linglong Kong University of Alberta
J K
John Kornak University of California, San Francisco
L L
Liza Levina University of Michigan
L L
Lexin Li University of California, Berkeley
T L
Tengfei Li University of North Carolina, Chapel Hill
M L
Martin Lindquist Johns Hopkins University
X ( L
Xi (Rossi) Luo UTHealth Houston
T M
Tianwen Ma Emory University
L M
L Mahadevan Harvard University
A M
Amanda Mejia Indiana University
T N
Thomas Nichols University of Oxford
L O
Lauren O’Donnell Brigham and Women’s Hospital
H O
Hernando Ombao KAUST
H P
Hanchuan Peng Institute for Brain and Intelligence
X P
Xavier Pennec INRIA
D R
Daniel Rowe Marquette University
H S
Heather Shappell Wake Forest University School of Medicine
L S
Li Shen University of Pennsylvania
A S
Ali Shojaie University of Washington
H S
Hai Shu New York University
S S
Sean Simpson Wake Forest University School of Medicine
A S
Anuj Srivastava Florida State University
W T
Wesley Thompson Laureate Institute for Brain Research
D T
Duygu Tosun-Turgut University of California, San Francisco
D T
Dana Tudorascu University of Pittsburgh
M V
Marina Vannucci Rice University
Y W
Yuping Wang Tulane University
C Y
Carl Yang Emory University
L Y
Laurent Younes Johns Hopkins University
T Z
Tingting Zhang University of Pittsburgh
Z Z
Zhengwu Zhang University of North Carolina, Chapel Hill
B Z
Bingxin Zhao University of Pennsylvania
Y Z
Yize Zhao Yale University
H Z
Hongtu Zhu University of North Carolina

Schedule

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Monday, August 26, 2024
8:30-8:55 CDT
Check-in and Breakfast
8:55-9:00 CDT
Welcome
9:00-9:50 CDT
Identification of Interacting Neural Populations: Ideas, Issues, and Personal Experience

Plenary Speaker: Robert Kass (Carnegie Mellon University, Statistics & Data Sciences)

9:50-10:00 CDT
Q&A
10:00-10:15 CDT
Coffee Break
10:15-11:15 CDT
Morning Session: Deep Learning (Chair: Jian Kang)

Speakers:

    “Graph Neural Networks for Brain Connectome Analysis,” Carl Yang (Emory University)
    “Dynamic resting state functional connectivity A time-varying dynamic network model,” Fei Jiang (University of California)
    “Doubly Adaptive Spatial Quantile Regression for Neuroimaging Data,” Linglong Kong (University of Alberta)
    “Deciphering Relationships between Massive High-Dimensional Imaging Responses and Scalar Predictors: A Distributed Learning Approach”, Lily Wang (George Mason University)

11:15-11:30 CDT
Q&A
11:30-12:30 CDT
Lunch Break
12:30-13:30 CDT
Afternoon Session: Functional Connectome (Chair: Tingting Zhang)

Speakers:

    “Changepoint Analysis in a Mixed Model Framework, With Applications to fMRI Time Series,” Mark Fiecas (University of Minnesota)
    “The hidden cost of stringent motion scrubbing,” Amanda Mejia (Indiana University)
    “Statistical Brain Network Analysis: Recent Developments and Future Directions,” Sean Simpson (Wake Forest University)
    “Analysis of Functional Connectivity Changes from Childhood to Old Age: A Study Using HCP-D, HCP-YA, and HCP-A Datasets”, Tingting Zhang (University of Pittsburgh)

13:30-13:45 CDT
Q&A
13:45-14:00 CDT
Coffee Break
14:00-15:00 CDT
Afternoon Session: Imaging Processing (Chair: Sean Simpson)

Speakers:

    Processing Induced Correlation in FMRI Data, Daniel Rowe (Marquette University)
    “Sliding windows analysis can undo the effects of preprocessing when applied to fMRI,” Martin Lindquist (Johns Hopkins University)
    “A Hidden Semi-Markov Model Approach to State-Based Dynamic Brain Network Analyses: Recent Developments and Future Directions”, Heather Shappell (Wake Forest University School of Medicine)
    Utilizing Invariance and Exchangeability in Neuroimaging Data Analyis, Yi Zhao (Indiana University)

15:00-15:15 CDT
Q&A
15:15-16:15 CDT
Panel: Brain Behavior and Synchronization (Chair: Eardi Lila)

Panelists:

    Robert Kass (Carnegie Mellon University)
    Tianwen Ma (Emory University)
    Jun Young Park (University of Toronto)

Tuesday, August 27, 2024
8:30-8:55 CDT
Check-in and Breakfast
9:00-9:50 CDT
Plenary Talk: Scale Matters: The Nested Human Connectome

Plenary Speaker: Markus Axer (Institute of Neurosciences and Medicine (INM-1), Research Centre Jülich)

9:50-10:00 CDT
Q&A
10:00-10:15 CDT
Coffee Break
10:15-11:15 CDT
Morning Session: Data Integration (Chair: Tingting Zhang)

Speakers:

    “Longitudinal Manifold Learning for Modeling Shapes in Alzheimer’s Disease”, Ani Eloyan (Brown University)
    “The Missing Link: Establishing the Parallels Between Censored Covariate and Missing Data,” Tanya Garcia (University of North Carolina at Chapel Hill)
    Some Recent and Ongoing Work on Intracranial Neurodata Analysis, Lexin Li (University of California, Berkeley)
    “Orthogonal common-source and distinctive-source decomposition between high-dimensional data views,” Hai Shu (New York University)

11:15-11:30 CDT
Q&A
11:30-12:30 CDT
Lunch Break
12:30-13:30 CDT
Afternoon Session: Applications to Neurological and Mental Diseases (Chair: John Kornak)

Speakers:

    Statistical regularization used to study brain structure, function, and connectivity: current work and future directions, Jaroslaw Harezlak (Indiana University Bloomington)
    “Disease progression modeling for frontotemporal dementia,” John Kornak (University of California)
    “Statistical Challenges in analysis of tau PET imaging data in Alzheimer’s Disease,” Dana Tudorascu (University of Pittsburgh)
    “Multidimensional Biomarker Landscape in Alzheimer’s Disease: Insights for Improved Disease Modeling and Clinical Trial Design,” Duygu Tosun-Turgut (University of California)

13:30-13:45 CDT
Q&A
13:45-14:15 CDT
Coffee Break
14:15-15:15 CDT
Afternoon Session: Bayesian Methods (Chair: Jian Kang)

Speakers:

    “Bayes in Neuroscience: Addressing Key Research Challenges with Single and Multi-Object Data”, Sharmistha Guha (Texas A&M University)
    “Challenges in Functional Near-infrared Spectroscopy,” Timothy Johnson (University of Michigan)
    “Bayesian Methods in EEG-Based Brain-Computer Interfaces,” Tianwen Ma (Emory University)
    “Opportunities and Challenges in the Analysis of Event-Related Potentials,” Marina Vannucci (Rice University)

15:15-15:30 CDT
Q&A
15:30-16:30 CDT
Panel: Population Neurosciences (Moderator: Chao Huang)

Panelists:

    Tom Nichols (University of Oxford)
    Li Shen (University of Pennsylvania)
    Dana Tudorascu (University of Pittsburgh)
    Wesley Thompson (Laureate Institute for Brain Research)

Wednesday, August 28, 2024
8:30-8:55 CDT
Check-in and Breakfast
9:00-9:50 CDT
Plenary Talk: Analyzing and Modelling Spatio-temporal patterns

Plenary Speaker: Jianfeng Feng (University of Warwick)

9:50-10:00 CDT
Q&A
10:00-10:30 CDT
Coffee Break
10:30-11:30 CDT
Morning Session: Shape Analysis (Chair: Anju Srivastava)

Speakers:

    “Atlas-to-data alignment of spatially-resolved transcriptomics data,” Laurent Younes (Johns Hopkins University)
    “Cortical convolutions: morphogenesis and morphometry,” L Mahadevan (Harvard University)
    Which Riemannian metric for statistics in connectomics?, Xavier Pennec (INRIA)
    “Statistical Shape Analysis of Complex Natural Structures,” Anuj Srivastava (Florida State University)

11:30-11:45 CDT
Q&A
11:45-12:45 CDT
Lunch Break
12:45-13:45 CDT
Afternoon Session: Structural Connectome (Chair: Zhengwu Zhang)

Speakers:

    “Challenges & opportunities in tractography: from classical techniques to futuristic machine learning,” Maxime Descoteaux (Université de Sherbrooke)
    “Defining and Quantifying the Brain’s White Matter Bundles,” Lauren O’Donnell (Brigham and Women’s Hospital)
    “Connectome-based spatial statistics using a function-aware structural connectome atlas,” Tengfei Li (University of North Carolina, Chapel Hill)
    “Continuous and Atlas-free Analysis of Brain Structural Connectivity,” Zhengwu Zhang (University of North Carolina, Chapel Hill)

13:45-14:00 CDT
Q&A
14:00-14:30 CDT
Coffee Break
14:30-15:30 CDT
Afternoon Session: Causality Research (Chair: Hernando Ombao)

Speakers:

    “Graphical Modeling and Spectral Analysis: New Directions and Challenges,” Sumanta Basu (Cornell University)
    “Challenges in Causal Inference from fMRI: Time Series, Networks, Interpretation, and Assumptions,” Xi (Rossi) Luo (UTHealth Houston)
    “Modeling Dependence and Testing for Causality Via Spectral Entropy,” Hernando Ombao (KAUST)
    “Non-stationarity in brain imaging data: challenges and opportunities,” Ali Shojaie (University of Washington)

15:30-15:45 CDT
Q&A
15:45-16:45 CDT
Panel: Increasing Research Speed and Impact of Imaging Statistics (Chair: Hongtu Zhu)

Panelists:

    Tom Nichols (University of Oxford)
    Hernando Ombao (KAUST)
    Anuj Srivastava (Florida State University)
    Michele Guindani (UCLA)

Thursday, August 29, 2024
8:30-8:55 CDT
Check-in and Breakfast
9:00-9:50 CDT
Plenary Talk: Scalable Approaches to Modelling Longitudinal Neuroimaging Data

Plenary Speaker: Thomas Nichols (University of Oxford)

9:50-10:00 CDT
Q&A
10:00-10:30 CDT
Coffee Break
10:30-11:30 CDT
Morning Session: Imaging Genetics (Chair: Hongtu Zhu)

Speakers:

    “Enhancing Dementia Studies with AI and Informatics: Strategies for Mining Brain Imaging Genomics Data,” Li Shen (University of Pennsylvania)
    “Integrative analysis of multi-modal MRI and genomics data: from linear to deep collaborative learning,” Yuping Wang (Tulane University)
    “Multi-organ imaging-derived polygenic indexes,” Bingxin Zhao (University of Pennsylvania)
    “Heritability and Genetic Contribution Analysis of Structural-Functional Coupling in Human Brain”, Yize Zhao (Yale University)

11:30-11:45 CDT
Q&A
11:45-12:45 CDT
Lunch Break
12:45-13:45 CDT
Afternoon Session: Population Neurosciences (Chair: Tom Nichols)

Speakers:

    “Scalable Bayesian Image-on-Scalar Regression for Population-Scale Neuroimaging Data Analysis,” Jian Kang (University of Michigan)
    “Network-aware connectome analysis,” Liza Levina (University of Michigan)
    ” Annotation-Informed Variance Components Model for Whole-Brain Associations,” Wesley Thompson (Laureate Institute for Brain Research)
    “Neuroimaging Data Analysis in the Era of Data Science and AI,” Hongtu Zhu (University of North Carolina)

13:45-14:00 CDT
Coffee Break
13:45-14:00 CDT
Q&A
14:00-16:00 CDT
Poster Session
Friday, August 30, 2024
8:30-8:55 CDT
Check-in and Breakfast
9:00-9:50 CDT
Plenary Talk: Toward building a whole brain connectome at single neuron resolution

Plenary Speaker: Hanchuan Peng (Institute for Brain and Intelligence)

9:50-10:00 CDT
Q&A
10:30-11:30 CDT
Panel: Brain Connectome (Chair: Yi Zhao)

Panelists:

    Markus Axer (Institute of Neurosciences and Medicine (INM-1), Research Centre Jülich)
    Shuo Chen (University of Maryland)
    Moo Chung (University of Wisconsin, Madison)
    Ivor Cribben (University of Alberta)
    Maxime Descoteaux (Université de Sherbrooke)

11:30-11:45 CDT
Workshop Survey

Poster Session

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The posters that have been submitted in advance for the poster session are available on the poster session page.